姜黄为姜科姜黄属植物姜黄 Curcuma longa L.的干燥根茎，常用来治疗胸胁刺痛、闭经等疾病。姜黄提取物（Curcumae Longae Rhizoma extract，CLRE）是从姜黄中分离得到的 β-二酮类多酚提取物，其中主要包括姜黄素、去甲氧基姜黄素和双去甲氧基姜黄素[1]。有研究表明 CLRE 可以通过抑制代谢途径改善肾纤维化症状，保护肾功能，改善肾损伤，治疗糖尿病肾病[2-4]。但 CLRE 水溶性差，生物利用度低，成为限制其临床应用的主要因素[5]。因此，提高 CLRE 溶解度及生物利用度的研究有利于 CLRE 的利用和临床使用。近几年，不少研究者通过把姜黄素、去甲氧基姜黄素、双去甲氧基姜黄素制备成其他剂型来解决溶解度差的问题[6-8]。
…………
1.2 试药与试剂
……对照品姜黄素（质量分数≥98%，批号 DST200412-014）、去甲氧基姜黄素（质量分数≥98%，批号 DST190910-030）、双去甲氧基姜黄素（质量分数≥98%，批号 DST191009-021），均购自成都德思特生物科技有限公司。
…………
DOI: 10.7501/j.issn.0253-2670.2022.01.013
Three-dimensional characteristic chromatogram by online comprehensive two-dimensional liquid chromatography: Application to the identification and differentiation of ginseng from herbal medicines to various Chinese patent medicines
A practical strategy enabling more reliable identification of ginsenosides from Panax quinquefolius flower by dimension-enhanced liquid chromatography/mass spectrometry and quantitative structure-retention relationship-based retention behavior prediction
Unveiling the chemical components variation of Sishen formula induced by different prescription ratios by the advanced liquid chromatography/mass spectrometry approaches
Machine learning prediction for constructing a universal multidimensional information library of Panax saponins (ginsenosides)
In vitro and in vivo metabolic activation and hepatotoxicity of chlorzoxazone mediated by CYP3A
A comprehensive strategy integrating metabolomics with DNA barcoding for discovery of combinatorial discriminatory quality markers: A case of Cimicifuga foetida and Cimicifuga dahuric
推荐阅读
热门阅读
结构类型
-->